China: Researchers discover therapeutic target for triple-negative breast cancer

Beijing, November 13 (Petra) – Chinese researchers have discovered a new therapeutic target for triple-negative breast cancer, which may contribute to discovering new solutions to treat this aggressive disease in an accurate way.
The newly discovered target is a type of tumor-specific transcript (TST), according to findings published this week in the Proceedings of the National Academy of Sciences of the United States of America.
Tumor-specific transcripts are derived from abnormal RNA synergy in cancer cells, and these transcripts are a factor in the development of cancer cells.
Triple-negative breast cancer has a much higher risk, although it is a subtype of breast cancer, due to its recurrence and spread compared to other subtypes, and the treatment of this type of disease is still insufficient, due to the lack of effective treatment targets available.
Researchers from Shanghai Cancer Center of Fudan University discovered a large number of tumor-specific copies in triple-negative breast cancer cells, with collagen-structured macrophage receptor (micro-test) being the most expressed type.
They found that expression of collagen-structured macrophage receptors was associated with poor outcomes in patients with this breast cancer subtype, and was a major factor promoting tumor progression, said Shao Zhimin, one of the research leaders.
He added that another study confirmed that the expression of the newly identified therapeutic target can be inhibited by BAT inhibitors, which is expected to become a solution for the precise treatment of tumors.
— (Petra)

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11/13/2022 10:06:58