RSB advanced thanks to a brace from Youssef Zghoudi (5′, 15′) and a strike from Reda Hajji (83′), while the hosts saved face through Haytam Manaout’s own goal scored at 87′.
The Moroccan club had previously beaten Angola’s CD Lunda Sul 2-0 on the first day.
In the group’s other match, Stade Malien were held to a 1-1 draw by CD Lunda Sul.
At the end of the matchday, RSB leads the group with 6 points, ahead of Stade Malien (4 pts). Desportivo Lunda-Sul are third with one point, while Stellenbosch are last with no points.
On the next matchday, scheduled for Sunday, RS Berkane faces Stade Malien (8:00 p.m.).